Examinando por Autor "Londoño-López, M. E. (Marta Elena)"
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Publicación Acceso abierto Características cristaloquímicas de la hidroxiapatita sintética tratada a diferentes temperaturas(2014-05-07) Londoño-López, M. E. (Marta Elena); Echavarría-Velásquez, A. (Alejandro); Calle, F. (Franzenith de la)Synthetic Hydroxyapatite (HA) is a calcium phosphate whose chemical composition is very similar to that present in human bones. This characteristic makes it biocompatible with live tissue. Due to this biocompatibility, it is possible to use HA in many medical applications. In this research, crystalochemical properties of HA obtained by different thermal treatments and put later in physiological Ringer solution, during 5 and 30 days, were followed. Conductivity measurement and analysis by spectrophotometric UV-VIS, selective ion, DRX, FTIR, and SEM showed the high dependence of crystalinity of both thermal treatment and higher solubility of the more crystalline samples. Besides, when the samples were immersed in Ringer solution, the competition between two mechanisms, dissolution and precipitation, was reveled.Publicación Acceso abierto Fabricación y caracterización de una matriz tridimensional de Hidroxiapatita Macroporosa para aplicación en ingeniería de tejidos óseos(2014-05-08) Rincón, M. (Marcela); Rodríguez, A. (Alejandra); Londoño-López, M. E. (Marta Elena); Echavarría-Velásquez, A. (Alejandro)Bone tissue engineering came up as a new option treatment for different kinds of illness, among them bone diseases. All this development has allowed solving multiple medical problems. The development of a hydroxyapatite scaffold for bone cells culture will be another alternative to attend several diseases that are caused on bones and that usually lead to disabilities in people. In this study synthetic hydroxyapatite was produced by a precipitation route with amonium phosphate (NH4H2PO4) and calcium nitrate (Ca(NO3)2*4H2O) as precursors.Publicación Acceso abierto Hidrogeles. Potenciales biomateriales para la liberación controlada de medicamentos(2014-04-23) Arredondo-Peñaranda, A. (Alejandro); Londoño-López, M. E. (Marta Elena)With traditional methods in drug release, poor controls are obtained about the ideals therapeutic levels that are required by the treatments. Due to these anomalies, the drug that initially was effective for the treatment of aforementioned disease, may not be administered in the required amount, at the right time and the expected location for effective treatment. On the other hand the rise, in recent years, about hydrogels as delivery systems, shows new alternatives to do an exact control in the fi eld of drug delivery. In the present review, are shown the main properties about these interesting biomaterials, in addition to the drugs conditions to be take into account and then the basis that involve design and production of drug delivery systems based on hydrogels.Publicación Acceso abierto Síntesis y caracterización de hidrogeles de alcohol polivinílico por la técnica de congelamiento/descongelamiento para aplicaciones médicas(2013-11-26) Echeverri-Cuartas, C. E. (Claudia Elena); Vallejo-Giraldo, Catalina; Londoño-López, M. E. (Marta Elena)Using different cycles of freeze-thawing, semicrystalline polyvinyl alcohol hydrogels were synthesized in concentrations of 7.5 % and 12 %. The kinetic and grade of swelling, states of water and the tensile strength were calculated by gravimetry, by differential scanning calorimetry, DSC, and the tensile tests respectively. The results show that hydrogels with less concentration and cycles have better grade and kinetic of swelling, while the tensile strength is lower. The DSC results allow us to determine the free and freezable bound waters in our hydrogels. The characteristics obtained from these hydrogels lead their classification for different medical applications.